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】【打印】【封闭窗口 来路:本站原创 著作人:统计与数学学院 编辑:张薇 公布日期:2019-11-26
      陈诉标题:Assisted Estimation of Gene Expression Graphical Models
      日期:2019年11月29日(周五)10:00 a.m.

      择要:In the study of gene expression data, network analysis has played a uniquely important role. To accommodate the high dimensionality and low sample size and generate interpretable results, regularized estimation is usually conducted in the construction of gene expression Gaussian Graphical Models (GGMs). Gene expressions are regulated by regulators. To better decipher the interconnections among gene expressions, conditional GGMs (cGGMs), which accommodate gene expressions as well as their regulators, have been constructed. In practical data analysis, the construction of both GGMs and cGGMs is often unsatisfactory, mainly caused by the large number of model parameters and limited sample size. In this article, we recognize that, with the regulation between gene expressions and regulators, the sparsity structures of the GGMs and cGGMs satisfy a hierarchy. Accordingly, we propose a joint estimation which reinforces the hierarchical structure and use GGMs to assist the construction of cGGMs and vice versa. Consistency properties are rigorously established, and an effective computational algorithm is developed. In simulation, the assisted construction outperforms the separation construction of GGMs and cGGMs. Two TCGA datasets are analyzed, leading to findings different from the direct competitors. Beyond gene expression data, the proposed approach can be potentially applied to a variety of other high dimensional network analysis.

      张庆昭,现为厦门大学经济学院统计系和王亚南经济研讨院副传授、博士生导师。2013年取得中国迷信院数学与条理迷信研讨院概率论与数理统计博士学位,先后在中国迷信院大学和美国耶鲁大学停止博士后研讨。次要研讨偏向为高维数据剖析、多源数据交融、函数数据剖析、统计学习和数据发掘等,在JASA、Biometrics、Statistica Sinica等统计学顶级期刊和一流期刊发布论文30余篇。国际统计学会推选会员,掌管国度自科面上、青年各1项,教诲部基金1项。